Intestinal Permeability profile (Biolab - PEG)

anatomy intestines low res.jpg
anatomy intestines low res.jpg

Intestinal Permeability profile (Biolab - PEG)


PEG / urine testing providing a measurement of Intestinal permeability or ‘leaky gut’, which can occur if there has been degradation to the ‘tight junctions’ which are found between the cells that make up the lining of the digestive tract.

sample type: urine

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sample type: urine
turnaround time: 7-14 days
Location: home
Biolab Datasheet
Example Report

Changes in permeability of the small intestine can lead to malabsorption either due to poor uptake of nutrients or over-absorption of partially digested food particles and other toxins or metabolites found in the digestive tract.  This test provides a useful tool to assess if intestinal permeability is a occurring or via repeat tests to monitor the progress of a gut repair protocol.

Leaky gut may be caused by an imbalance in gut flora (dysbiosis), the presence of parasites, yeasts or other pathogenic microbes or dysfunction in the digestive tract such as poor production of stomach acid or bile salts.  Ingestion of ‘problem’ foods or other irritants such as NSAID painkillers, aspirin can also increase intestinal permeability.

Symptoms which may be associated with intestinal permeability include:

-        Digestive discomfort
-        Diarrhoea or constipation
-        Indigestion or bloating
-        Fatigue
-        Allergies (skin, asthma)
-        Poor concentration, brain fog, mood swings
-        Headaches
-        Poor immunity

Conditions which may be associated with intestinal permeability include:

-        Atopic allergies such as eczema, psoriasis
-        Food intolerance
-        Irritable bowel syndrome (IBS)
-        Inflammatory bowel disease (IBD)
-        Autoimmune conditions including Coeliac’s disease, rheumatoid arthritis, psoriasis

If this test confirms that intestinal permeability is present, further testing such as stool or SIBO testing may be helpful to understand the underlying cause.

The sample required for the gut permeability profile is a 6 hour urine collection after a 3 gram oral dose of PEG. A 20 mL sample of the total urine collection may be sent for analysis if the volume of the total collection can be accurately measured.

The patient should fast for 3 hours before starting the test and during the test. Water intake during the first 2 hours of the 6 hour urine collection should be limited to 250 mL. Water consumption during the remainder of the test should be moderate.

The PEG test should not be performed if the patient has gastroenteritis or is suffering from any other cause of intestinal hurry, as this will invalidate the urinary reference interval for the recovery of PEG.

The constipation medication Movicol contains PEG
The supplement 7 Seas Zinc plus Vitamin C contains PEG
Some osmotic diuretics and renal vasodilators contain PEG
If you are taking any of the above please discuss with Biolab prior to proceeding.

Postal samples done at home must reach Biolab within 3 days of collection. Please note that samples should only be posted on Monday - Thursday for Friday delivery - this avoids samples being delayed over the weekend period.